InterPro domain: IPR032446

This entry represents a short highly conserved region close to the N terminus of SCAPER. SCAPER is an ER-localised protein and a substrate for cyclin A/Cdk2. One theory suggests that SCAPER functions to create a local high concentration of cyclin A2 in the cytoplasm. Alternatively, SCAPER might be acting to sequester a portion of cellular cyclin A2 that could then be readily available for nuclear translocation, which may be needed for exit from G0 phase [ 1 , 2 ].

1. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. J. Cell Biol. 178, 621-33
2. The endoplasmic reticulum takes center stage in cell cycle regulation. Sci Signal 1, pe4