InterPro domain: IPR032378

This entry represents the C-terminal domain of the translation machinery-associated protein 46 (Tma46), a binding partner for the highly conserved developmentally regulated GTP-binding (DRG) GTPases. The interaction between Tma46 and Rbg1 GTPase (a DRG protein) modulates the function of the GTPase [ 1 ]. This domain is also found in ZC3H15 (zinc finger CCCH domain-containing protein 15), also known as DFRP1 (DRG family regulatory protein 1) [ 2 ].

1. Rbg1-Tma46 dimer structure reveals new functional domains and their role in polysome recruitment. Nucleic Acids Res. 40, 11100-14
2. Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML. Int. J. Oncol. 43, 246-54