InterPro domain: IPR032302
General Information
- Identifier IPR032302
- Description THO complex subunit 2, N-terminal domain
- Number of genes 130
- Gene duplication stats Loading...
Abstract
This entry represents the N terminus of THO complex subunit 2 (THO2, THOC2) [ 1 , 2 ].
THO/TREX, a nuclear protein complex conserved from yeast to humans, plays an important role in mRNP biogenesis connecting transcription elongation, mRNA export and preventing genetic instability. THO could be relevant to different mRNA processing steps, including the 3'-end formation, transcript release and export [ 3 ].
1. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 19, 1512-7
2. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J. 19, 5824-34
3. New clues to understand the role of THO and other functionally related factors in mRNP biogenesis. Biochim. Biophys. Acta 1819, 514-20