InterPro domain: IPR032270

General Information

  • Identifier IPR032270
  • Description AMPK, C-terminal adenylate sensor domain
  • Number of genes 5
  • Gene duplication stats Loading...

Abstract

This domain can be found at the C terminus of yeast SNF1 and animal 5'-AMP (adenosine monophosphate)-activated protein kinase (AMPK) subunit alpha [ 1 ]. The yeast SNF1 kinase is a prototype of AMPKs that regulate cellular responses to a variety of nutritional and environmental stresses [ 2 ].


1. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 315, 1726-9
2. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67, 821-55

Species distribution

Gene table