InterPro domain: IPR032264

This entry represents the middle domain of menaquinone biosynthesis protein MenD, an enzyme that belongs to the thiamine pyrophosphate (TPP) enzyme family, but is not captured by IPR012000 . This enzyme is necessary for the first step of the biosynthesis of menaquinone, or vitamin K2, an important cofactor in electron transport in bacteria [ 1 ].

1. Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase). J. Mol. Biol. 384, 1353-68