InterPro domain: IPR032245

The dissolvasome is a protein complex that consists of BLM, a RecQ helicase that is product of the gene mutated in Bloom syndrome, topoisomerase IIIalpha (Top3alpha) and the RMI (RecQ-mediated genome instability) subcomplex, comprised of RMI1 and RMI2. The dissolvasome acts on double Holliday junction intermediates in homologous recombination, creating non-crossover products in a process termed 'dissolution' [ 1 , 2 ].

RMI2 is an OB3, oligo-nucleotide-binding protein. It is an essential component of the RMI complex [ 3 ].

1. The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature 426, 870-4
2. BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc. Natl. Acad. Sci. U.S.A. 103, 4068-73
3. Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome. Structure 18, 1149-58