InterPro domain: IPR032190

General Information

  • Identifier IPR032190
  • Description Niemann-Pick C1, N-terminal
  • Number of genes 198
  • Gene duplication stats Loading...

Abstract

This is the N-terminal domain of Niemann-Pick C1 family proteins, which mediate transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket [ 1 , 2 ].


1. Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1. Genomics 65, 137-45
2. The structure of the NPC1L1 N-terminal domain in a closed conformation. PLoS ONE 6, e18722

Species distribution

Gene table