InterPro domain: IPR032154

This entry represents the very C-terminal domain of the eukaryotic Coatomer subunit gamma proteins. It acts as a platform domain to the C-terminal appendage. It carries one single protein/protein interaction site, which is the binding site for ARFGAP2 or ADP-ribosylation factor GTPase-activating protein. COPI-coated vesicles mediate retrograde transport from the Golgi back to the ER and intra-Golgi transport. The gamma subunit is part of one of two subcomplexes that make up the heptameric coatomer complex along with the beta, delta and zeta subunits [ 1 ].

1. Gamma-COP appendage domain - structure and function. Traffic 5, 79-88