InterPro domain: IPR032009

This entry represents the two coiled-coil dimerisation domains of plant-specific actin-binding proteins or SCABs, CC1 and CC2, both of which contribute independently to dimerisation. CC1 is also required for actin binding, indicating that SCAB1 is a bivalent actin cross-linker, since CC1 adopts an antiparallel helical hairpin that further dimerises into a four-helix bundle. SCAB proteins bind, bundle and stabilise actin filaments and regulate stomatal movement [ 1 ].

1. Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain. J. Biol. Chem. 287, 11981-90