InterPro domain: IPR031846

Voltage-gated hydrogen channel 1 (Hvcn1, also known as Hv1 or VSOP) mediates the voltage-dependent proton permeability of excitable membranes. It forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient [ 1 ]. It is required for high-level superoxide production by phagocytes [ 2 ]. It has also been shown to regulate human sperm motility through activating alkalization-activated calcium channels [ 3 ]. The structure of Hvcn1 has been solved [ 4 ].

1. Aspartate 112 is the selectivity filter of the human voltage-gated proton channel. Nature 480, 273-7
2. Voltage-gated proton channel is expressed on phagosomes. Biochem. Biophys. Res. Commun. 382, 274-9
3. Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel. Cell 140, 327-37
4. X-ray crystal structure of voltage-gated proton channel. Nat. Struct. Mol. Biol. 21, 352-7