InterPro domain: IPR031693

This entry represents a domain found in the C-terminal of the transcriptional repressor Sin3.

Budding yeast Sin3 is a component of both the Rpd3S and Rpd3L histone deacetylase complexes [ 1 ]. In mammals there are two Sin3 paraologues, Sin3A and Sin3B. They forms the larger Sin3L/Rpd3L and the smaller Sin3S/Rpd3S complexes, both complexes rely largely on HDAC (histone deacetylase) activity to affect transcriptional repression. Sin3A and Sin3B may partition into the Sin3L/Rpd3L and Sin3S/Rpd3S complexes, respectively [ 2 ].

1. Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim. Biophys. Acta 1731, 77-87; discussion 75-6
2. Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex. Proc. Natl. Acad. Sci. U.S.A. 112, E3669-78