InterPro domain: IPR031691

Lipoyl synthase is an iron-sulphur protein [ 1 ]. It is localised to mitochondria in yeast and Arabidopsis [ 2 , 3 ]. It generates lipoic acid, a thiol antioxidant that is linked to a specific Lys as prosthetic group for the pyruvate and alpha-ketoglutarate dehydrogenase complexes and the glycine-cleavage system.

This domain is found in the N terminus of lipoyl synthases.

1. The lipoate synthase from Escherichia coli is an iron-sulfur protein. FEBS Lett. 453, 25-8
2. Isolation and characterization of LIP5. A lipoate biosynthetic locus of Saccharomyces cerevisiae. J. Biol. Chem. 268, 17634-9
3. The biosynthetic pathway for lipoic acid is present in plastids and mitochondria in Arabidopsis thaliana. FEBS Lett. 517, 110-4