InterPro domain: IPR031625

This entry represents the C-terminal acidic region of eukaryotic sodium channel modifier protein 1 (SCNM1). Deletion of this region affects the splicing and normal activity of the sodium channel Nav1.6 from gene Scn8a [ 1 ]. SCNM1 belongs to the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities. SCNM1 and LUC7L2 associate with the mammalian spliceosomal subunit U1 snRNP [ 2 ].

1. SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science 301, 967-9
2. Evidence for a direct role of the disease modifier SCNM1 in splicing. Hum. Mol. Genet. 16, 2506-16