InterPro domain: IPR031622

This C2H2 type zinc-finger is found at the N terminus of SCNM1, sodium channel modifier protein 1 [ 1 ]. Phylogenetic analysis of these zinc finger sequences places SCNM1 within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities [ 2 ].

1. SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science 301, 967-9
2. Evidence for a direct role of the disease modifier SCNM1 in splicing. Hum. Mol. Genet. 16, 2506-16