InterPro domain: IPR031425

NIMIN1/3 are linked to the salicylic acid-dependent systemic acquired resistance response (SAR), a plant immune response [ 1 ]. They interact via a motif at the C terminus with the regulatory protein NPR1 (also known as NIM1), a key regulator of SAR in Arabidopsis [ 2 ].

NH1 is the rice orthologue of NPR1, and NRR has been identified as an NH1 and NPR1 interactor [ 3 ]. NH1 is a transcriptional co-activator that represses NH1-mediated activation. NRR homologues 1, 2 and 3 (RH1, RH2, and RH3) have also been reported to bind to, and repress to varying degrees, NH1-mediated transcriptional activation [ 4 ]. RH1 and RH3, but not RH2, also effectively repress NH1-mediated transcriptional activation [ 5 ].

1. The Arabidopsis NIMIN proteins affect NPR1 differentially. Front Plant Sci 4, 88
2. NIMIN-1, NIMIN-2 and NIMIN-3, members of a novel family of proteins from Arabidopsis that interact with NPR1/NIM1, a key regulator of systemic acquired resistance in plants. Plant Mol. Biol. 46, 143-60
3. Rice NRR, a negative regulator of disease resistance, interacts with Arabidopsis NPR1 and rice NH1. Plant J. 43, 623-35
4. A rice transient assay system identifies a novel domain in NRR required for interaction with NH1/OsNPR1 and inhibition of NH1-mediated transcriptional activation. Plant Methods 8, 6