InterPro domain: IPR031255
General Information
- Identifier IPR031255
- Description Vacuolar protein sorting-associated protein 4
- Number of genes 1
- Gene duplication stats Loading...
Abstract
There are two mammalian VPS4 isoforms, VPS4A and VPS4B. They belong to the AAA ATPase family. VPS4A is a central regulator for early endosome trafficking [ 1 , 2 ]. VSP4 interacts with the ESCRT complex, which directs multiple cellular membrane remodelling events, ranging from the biogenesis of multivesicular bodies and exosomes to the final membrane abscission stage of cytokinesis [ 3 ]. The viral budding via host ESCRT complex can also be regulated by VPS4 [ 4 ].
1. Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. J. Mol. Biol. 312, 469-80
2. Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2. Biochem. J. 365, 349-53
3. Making sense of Vps4. J. Mol. Biol. 426
4. Structure of cellular ESCRT-III spirals and their relationship to HIV budding. Elife 3, 503-6