InterPro domain: IPR031150

BBP/SF1 family members include the branchpoint binding proteins (BBP) from yeast and their mammalian homologue, splicing factor 1 (SF1). They are KH domain containing proteins required for pre-spliceosome formation, which is the first step of pre-mRNA splicing [ 1 , 2 ]. In budding yeasts, BBP binds the conserved RNA sequence UACUAAC, called the branchpoint motif, found near the 3' end of yeast introns [ 3 ]. Besides its function in pre-mRNA splicing, BBP is also involved in nuclear retention of pre-mRNA [ 4 ]. Mammalian SF1, also known as ZFM1, may act as transcription repressor [ 4 ].

1. Pre-spliceosome formation in S.pombe requires a stable complex of SF1-U2AF(59)-U2AF(23). EMBO J. 21, 5516-26
2. A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing. EMBO J. 19, 1873-86
3. The branchpoint binding protein: in and out of the spliceosome cycle. Adv. Exp. Med. Biol. 693, 123-41
4. The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. J. Biol. Chem. 273, 18086-91