InterPro domain: IPR031143

Strigolactones (SLs) are phytohormones that inhibit shoot branching and function in the rhizospheric communication with symbiotic fungi and parasitic weeds [ 1 ]. This entry represents a group of plant strigolactone esterases, including DWARF 14 (D14) from Arabidopsis and DAD2 from Petunia hybrida [ 2 ]. They play a role in strigolactone perception and signalling [ 3 , 4 ]. The structure of D14 has been solved [ 5 ]. It covalently binds to D-ring of strigolactone and forms a stable complex essential for hormone bioactivity. The hydrolysis of strigolactone into a linked intermediate molecule induces a conformational change of D14 which facilitates interaction with MAX2 and formation of the D14-MAX2-SKP1/ASK1 complex to trigger strigolactone signaling [ 6 ].

1. Molecular mechanism of strigolactone perception by DWARF14. Nat Commun 4, 2613
2. Characterization of DWARF14 Genes in Populus. Sci Rep 6, 21593
3. DAD2 is an α/β hydrolase likely to be involved in the perception of the plant branching hormone, strigolactone. Curr. Biol. 22, 2032-6
4. d14, a strigolactone-insensitive mutant of rice, shows an accelerated outgrowth of tillers. Plant Cell Physiol. 50, 1416-24
5. Structures of D14 and D14L in the strigolactone and karrikin signaling pathways. Genes Cells 18, 147-60
6. DWARF14 is a non-canonical hormone receptor for strigolactone. Nature 536, 469-73