InterPro domain: IPR031137

Growth-regulating factors (GRFs) are transcription factors that play a regulatory role in growth and development of leaves and cotyledons [ 1 , 2 , 3 ]. Typical GRFs contain QLQ and WRC domains. The QLQ domain is involved in protein-protein interactions, while the WRC domain contains a nuclear localisation signal and a DNA-binding motif [ 4 ]. Arabidopsis have 9 GRF members (AtGRF1-9): AtGRF1 and AtGRF2 act as transcriptional activators; AtGRF1 and AtGRF3 contribute to the regulation of various biological processes associated with defense response and disease resistance; AtGRF7 has been reported to function as transcriptional repressor of osmotic stress-responsive genes by binding to the cis-element TGTCAGG [ 4 ].

1. Synchronization of developmental processes and defense signaling by growth regulating transcription factors. PLoS ONE 9, e98477
2. A transcriptional coactivator, AtGIF1, is involved in regulating leaf growth and morphology in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 101, 13374-9
3. Genetic interaction between GROWTH-REGULATING FACTOR and CUP-SHAPED COTYLEDON in organ separation. Plant Signal Behav 10, e988071