InterPro domain: IPR031121

This entry represents a group of KH domain containing proteins from eukaryotes, including RIK (rough sheath 2-interacting KH domain) from plants and BLOM7 (also known as KH homology domain-containing protein 4) from animals.

RIK1 interacts with rough sheath2 (RS2), which is a myb domain protein required to repress knox genes during leaf development [ 1 ].

BLOM7 is a RNA-binding protein involved in pre-mRNA splicing [ 2 ]. It has been shown to interact with SNEV (Prp19/Pso4), a splicing factor [ 3 ].

1. Maize rough sheath2 and its Arabidopsis orthologue ASYMMETRIC LEAVES1 interact with HIRA, a predicted histone chaperone, to maintain knox gene silencing and determinacy during organogenesis. Plant Cell 17, 2886-98
2. Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4. J. Biol. Chem. 284, 29193-204
3. Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA. PLoS ONE 7, e47497