InterPro domain: IPR031115

CPNA-1 is a copine domain protein required for muscle maintenance/stability in Caenorhabditis elegans [ 1 ]. It is localised to integrin adhesion sites in muscle tissue and might act as a linker between membrane proximal attachment proteins and those deeper within muscle cells. CPNA-1 contains a predicted transmembrane domain and is the first characterised copine domain-containing protein that lacks C2 domains. It is most similar to homologues in other nematodes, but it is also similar to mammalian copines.

1. CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans. Mol. Biol. Cell 24, 601-16