InterPro domain: IPR031105

This entry represents a group of plant telomere repeat-binding proteins, including AtTRP1-6 from Arabidopsis and RTBP1 from Oryza sativa subsp. japonica.

AtTRP1 binds specifically to the plant telomeric double-stranded DNA sequences 5'-GGTTTAG-3' [ 1 ]. It interacts with the ethylene receptor ERS1 and modulates development in Arabidopsis [ 2 ]. AtTRP4, also known as AtTBP1 (AT5G13820), is required for telomere length homeostasis and its Myb-extension domain stabilises plant telomeric DNA binding [ 3 ].

RTBP1 binds the telomeric double-stranded 5'TTTAGGG-3' repeat and can serve as a negative regulator of telomere length and one of positive and functional components for proper architecture of telomeres [ 4 , 5 ].

1. A plant gene encoding a Myb-like protein that binds telomeric GGTTTAG repeats in vitro. J. Biol. Chem. 276, 16511-9
2. AtTRP1 encodes a novel TPR protein that interacts with the ethylene receptor ERS1 and modulates development in Arabidopsis. J. Exp. Bot. 60, 3697-714
3. Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeostasis and its Myb-extension domain stabilizes plant telomeric DNA binding. Nucleic Acids Res. 35, 1333-42
4. Sequence-specific DNA recognition by the Myb-like domain of plant telomeric protein RTBP1. J. Biol. Chem. 275, 24208-14
5. Suppression of RICE TELOMERE BINDING PROTEIN 1 results in severe and gradual developmental defects accompanied by genome instability in rice. Plant Cell 19, 1770-81