InterPro domain: IPR031100

The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG and pyrimidine/purine nucleotide 5'-monophosphate nucleosidase ygdH. LOG converts inactive cytokinin nucleotides to the biologically active free-base forms [ 1 , 2 ]. YgdH may catalyse the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base [ 3 ].

1. Direct control of shoot meristem activity by a cytokinin-activating enzyme. Nature 445, 652-5
2. Functional analyses of LONELY GUY cytokinin-activating enzymes reveal the importance of the direct activation pathway in Arabidopsis. Plant Cell 21, 3152-69
3. Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli. Nat. Methods 14, 187-194