InterPro domain: IPR031059
General Information
- Identifier IPR031059
- Description High mobility group protein HMGA, plant
- Number of genes 227
- Gene duplication stats Loading...
- Associated GO terms GO:0003677 GO:0005634
Abstract
The plant high mobility group (HMG) proteins can be grouped into two families: HMGB (HMG 1/2) and HMGA (HMG I/Y). This entry represents the HMGA family from plants. HMGA binds specifically to AT-rich DNA through its AT-hook DNA binding motifs and is involved in diverse nuclear and cellular processes including chromatin organisation, DNA repair and gene transcription [ 1 , 2 ]. HMGA has been shown to bind four-way junction DNA [ 3 ].
1. The maize HMGA protein is localized to the nucleolus and can be acetylated in vitro at its globular domain, and phosphorylation by CDK reduces its binding activity to AT-rich DNA. Biochim. Biophys. Acta 1789, 751-7
2. Arabidopsis chromatin-associated HMGA and HMGB use different nuclear targeting signals and display highly dynamic localization within the nucleus. Plant Cell 18, 2904-18
3. Interaction of wheat high-mobility-group proteins with four-way-junction DNA and characterization of the structure and expression of HMGA gene. Arch. Biochem. Biophys. 409, 357-66