InterPro domain: IPR031047
General Information
- Identifier IPR031047
- Description DNA helicase Ino80
- Number of genes 153
- Gene duplication stats Loading...
- Associated GO terms GO:0016887 GO:0006281 GO:0005634 GO:0006338 GO:0006351 GO:0031011
Abstract
Ino80 is evolutionarily conserved from yeast to man [ 1 ]. It is a ATPase and a subunit of Ino80 complex [ 2 ]. The Ino80 complex displays 3'-5' DNA helicase activity and is involved in transcription, DNA replication and repair, and chromatin remodelling [ 3 , 4 , 5 ].
1. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. J. Biol. Chem. 286, 11283-9
2. Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. Biochem. Biophys. Res. Commun. 339, 313-20
3. The INO80 ATP-dependent chromatin remodeling complex is a nucleosome spacing factor. Mol. Cell. Biol. 31, 662-73
4. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. J. Biol. Chem. 280, 41207-12
5. The INO80 protein controls homologous recombination in Arabidopsis thaliana. Mol. Cell 16, 479-85