InterPro domain: IPR030828

This entry describes the C-terminal DNA-binding helix-turn-helix domain of several regulators of aromatic amino acid metabolism. Examples include TyrR in Escherichia coli and in Haemophilus influenzae, and PhhR in Pseudomonas putida [ 1 ]. Most members of this family have a sigma-54 interaction domain [ 2 ]. The TyrR protein of Escherichia coli can act both as a repressor and as an activator of transcription [ 3 ].

1. Expression, purification, and functional analysis of the TyrR protein of Haemophilus influenzae. Protein Expr. Purif. 10, 237-46
2. Solution structure of the DNA-binding domain of the TyrR protein of Haemophilus influenzae. Protein Sci. 10, 592-8
3. The TyrR regulon. Mol. Microbiol. 55, 16-26