InterPro domain: IPR030668
General Information
- Identifier IPR030668
- Description Spermidine/spermine synthase, eukaryotes
- Number of genes 249
- Gene duplication stats Loading...
- Associated GO terms GO:0006595
Abstract
The ubiquitous polyamines spermidine and spermine are involved in numerous cellular functions and they are essential for cell growth and proliferation. Spermidine synthase ( 2.5.1.16 ) (putrescine aminopropyltransferase) catalyses the last step in the biosynthesis of spermidine from arginine and methionine; the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor [ 1 ]. Spermine synthase ( 2.5.1.22 ) (spermidine aminopropyltransferase) converts spermidine into spermine using decarboxylated S-adenosylmethionine as the cofactor [ 2 ].
This entry consists of spermidine and spermine synthases from eukaryotes.
1. Structure and mechanism of spermidine synthases. Biochemistry 46, 8331-9
2. Spermine synthase. Cell. Mol. Life Sci. 67, 113-21