InterPro domain: IPR030666

General Information

  • Identifier IPR030666
  • Description tRNA isopentenyltransferase, eukaryotes

Abstract

The N(6)-(isopentenyl)adenosine (i(6)A) modification of some tRNAs at position A37 is found in all kingdoms and facilitates codon-specific mRNA decoding, but occurs in different subsets of tRNAs in different species [ 1 ]. This entry represents tRNA isopentenyltransferase from eukaryotes. It catalyses the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A) [ 2 ].


1. Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases. RNA 17, 1846-57
2. Cloning of a human tRNA isopentenyl transferase. Gene 258, 85-93

Species distribution

Gene table