InterPro domain: IPR030484

General Information

  • Identifier IPR030484
  • Description Serine/threonine-protein kinase Rio2
  • Number of genes 145
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004672  

Abstract

This entry represents the catalytic domain of protein Rio2 from archaea to human. Rio2 is a conserved serine protein kinase capable of in vitro autophosphorylation, albeit with low activity [ 1 ]. In budding yeast, the kinase activity of Rio2 is necessary for the final processing step of maturing the 18S ribosomal rRNA [ 2 ].


1. ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit. Nat. Struct. Mol. Biol. 19, 1316-23
2. Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes. FEBS J. 272, 2800-10

Species distribution

Gene table