InterPro domain: IPR030482

p53 and DNA damage-regulated protein 1 (PDRG) mRNA is upregulated by ultraviolet radiation (UV) but downregulated by tumour suppressor p53 [ 1 ]. Its expression is increased in multiple human malignancies, suggesting that it could play a role in cancer development and/or progression [ 2 ]. It belongs to the prefoldin subunit beta family, whose members are chaperone complex subunits. The function of PDRG is not clear.

1. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. Oncogene 22, 7247-57
2. PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress. Cancer Biol. Ther. 11, 567-73