InterPro domain: IPR030434

Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), also known as CRR9 (cisplatin resistance-related protein 9), is a transmembrane protein overexpressed in non-small cell lung cancer, where it protects tumour cells from genotoxic apoptosis [ 1 ]. It has been identified as an overexpressed protein in human ovarian tumour cell lines that are resistant to cisplatin [ 2 ]. CLPTM1L may protect cells from genotoxic stress induced apoptosis through regulation of Bcl-xL [ 3 ]. It interacts with phosphoinositide 3-kinase and is essential for Ras-induced AKT phosphorylation [ 3 ]. The CLPTM1L gene lies within a cancer susceptibility locus at chromosome 5p15.33 (TERT-CLPTM1L) defined by genome-wide association studies [ 3 ].

This entry also includes CLPTM1-like membrane protein cnrB from slime molds

1. CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis. Cancer Res. 74, 1116-27
2. Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. PLoS ONE 7, e36116