InterPro domain: IPR030369

ATP-binding cassette subfamily A member 7 (ABCA7) belongs to the ABC transporter family, whose remembers are full-length transporters organised in two tandem halves, each with a hydrophobic TMD followed by a cytoplasmic NBD [ 1 ].

In macrophages, ABCA7 functions in phagocytosis and can be stabilised by HDL (high-density lipoprotein) apolipoproteins [ 2 ]. ABCA7 has been linked to Alzheimer's disease pathogenesis [ 3 , 4 ]. It is also linked to Sjogrens syndrome, a chronic autoimmune disease characterised by the sicca symptoms of dry eyes and dry mouth [ 5 , 6 ].

1. Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport. Biochim. Biophys. Acta 1831, 555-74
2. Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J. Lipid Res. 25, 89-104
3. ABCA7 in Alzheimer's Disease. Mol. Neurobiol. 35, 2423.e7-2423.e13
4. ABCA7 gene and the risk of Alzheimer's disease in Han Chinese in Taiwan. Neurobiol. Aging 51, 2591-9
5. Immunopathogenesis of Sjogren's syndrome. Clin Rev Allergy Immunol 283, 1019-25
6. Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's Syndrome. Biochem. Biophys. Res. Commun.