InterPro domain: IPR030244

Yor1 is a plasma membrane protein from Saccharomyces cerevisiae that belongs to the ATP-binding cassette (ABC) transporter family. Yor1 mediates export of many different organic anions, including oligomycin. It is associated with rhodamine 6G and doxorubicin resistance and with rhodamine B transport [ 1 ].

The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [ 2 ].

1. Functional characterization of the Saccharomyces cerevisiae ABC-transporter Yor1p overexpressed in plasma membranes. Biochim. Biophys. Acta 1778, 68-78
2. The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 42, 1007-17