InterPro domain: IPR030231

GPN-loop GTPase 2 (Gpn2) belongs to the GPN-loop GTPase family [ 1 ]. It is also known as ATPBD1B in humans.

In budding yeasts, Gpn2 is a putative GTPase that has a role in biogenesis of RNA polymerase II and III [ 2 ]. It is involved in sister chromatid cohesion [ 3 ].

1. Structural insights into a new homodimeric self-activated GTPase family. EMBO Rep. 8, 569-75
2. Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae. Genetics 193, 853-64
3. Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN. Cell Cycle 12, 463-72