InterPro domain: IPR030101
General Information
- Identifier IPR030101
- Description SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
- Number of genes 160
- Gene duplication stats Loading...
- Associated GO terms GO:0036310 GO:0006281 GO:0031297
Abstract
HARP (HepA-related protein; also known as SMARCAL1 and DNA-dependent ATPase A) is an ATP-driven annealing helicase that acts throughout the genome to re-anneal stably unwound DNA [ 1 ]. It helps to stabilise stalled replication forks and facilitate DNA repair during replication [ 2 , 3 ]. SMARCAL1 binds directly to forked DNA structures or can be recruited to replication forks via interaction with the single-stranded DNA binding protein RPA [ 4 ]. Mutations in the HARP gene are responsible for a pleiotropic disorder known as Schimke immuno-osseous dysplasia (SIOD) [ 5 ].
1. HARP is an ATP-driven annealing helicase. Science 322, 748-50
2. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep. 12, 574-80
3. Targeting SMARCAL1 as a novel strategy for cancer therapy. Biochem. Biophys. Res. Commun. 427, 232-5
4. SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication. Genes Dev. 26, 151-62