InterPro domain: IPR030048

General Information

  • Identifier IPR030048
  • Description Survival protein SurE
  • Number of genes 373
  • Gene duplication stats Loading...
  • Associated GO terms GO:0008252  

Abstract

SurE is one of the several proteins that is expressed when bacterial cells are subjected to environmental stresses and in the stationary growth phase of bacteria [ 1 , 2 ]. In E. coli, surE is next to pcm, an L-isoaspartyl protein repair methyltransferase that is also required for stationary phase survival. It was originally predicted to be an acid phosphatase, however, subsequent work showed this is not the case [ 3 ]. SurE has been shown to possess phosphatase activity and appears to be specific to nucleoside monophosphates [ 4 ]. In E. coli, Thermotoga maritima, and Pyrobaculum aerophilum SurE acts strictly on nucleoside 5'- and 3'-monophosphates.


1. Growth-phase-dependent transcriptional regulation of the pcm and surE genes required for stationary-phase survival of Escherichia coli. Microbiology (Reading, Engl.) 143 ( Pt 11), 3513-20
2. Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase. Structure 9, 1095-106
3. General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG. J. Biol. Chem. 279, 54687-94
4. Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity. J. Mol. Biol. 326, 1559-75

Species distribution

Gene table

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