InterPro domain: IPR030008

Scarecrow-like 3 (SCL3) is a GRAS transcription regulator [ 1 ] that functions as a positive regulator of gibberellin (GA) signalling [ 2 ]. Gibberellins are plant hormones that modulate growth and development throughout the whole life cycle of the flowering plant. SCL3 and transcriptional factor DELLA antagonize each other in controlling both downstream GA responses and upstream GA biosynthetic genes [ 3 ]. Both coregulators DELLA and SCL3 use intermediate domain proteins (IDDs) as transcriptional scaffolds for DNA binding [ 4 ].

1. The GRAS gene family in Arabidopsis: sequence characterization and basic expression analysis of the SCARECROW-LIKE genes. Plant J. 18, 111-9
2. Funneling of gibberellin signaling by the GRAS transcription regulator scarecrow-like 3 in the Arabidopsis root. Proc. Natl. Acad. Sci. U.S.A. 108, 2166-71
3. Scarecrow-like 3 promotes gibberellin signaling by antagonizing master growth repressor DELLA in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 108, 2160-5
4. DELLA protein functions as a transcriptional activator through the DNA binding of the indeterminate domain family proteins. Proc. Natl. Acad. Sci. U.S.A. 111, 7861-6