InterPro domain: IPR029787

A common fold is found in the adenylyl and guanylyl cyclase catalytic domain and the diguanylate cyclase (DGC or GGDEF) domain. It consists of a ferredoxin-like fold with additional secondary structures. Though the fold of the GGDEF domain is similar to adenylate cyclase, the nucleotide-binding mode is substantially different [ 1 ].

1. Structural basis of activity and allosteric control of diguanylate cyclase. Proc. Natl. Acad. Sci. U.S.A. 101, 17084-9