InterPro domain: IPR029732
General Information
- Identifier IPR029732
- Description WTAP/Mum2 family
- Number of genes 198
- Gene duplication stats Loading...
- Associated GO terms GO:0005634 GO:0080009
Abstract
The Wtap family includes female-lethal(2)D from Drosophila and pre-mRNA-splicing regulator WTAP from mammals. The former is required for female-specific splicing of Sex-lethal RNA [ 1 ], and the latter is a regulatory subunit of the RNA N6-methyladenosine methyltransferase [ 2 ]. The family also includes the yeast Mum2p protein which is part of the Mis complex, a complex that mediates N6-methyladenosine methylation on some mRNAs during meiosis and is required for sporulation [ 3 , 4 ].
1. The Drosophila melanogaster fl(2)d gene is needed for the female-specific splicing of Sex-lethal RNA. EMBO J. 9, 2597-602
2. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 24, 177-89
3. RNA methylation by the MIS complex regulates a cell fate decision in yeast. PLoS Genet. 8, e1002732
4. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 155, 1409-21