InterPro domain: IPR029602

General Information

  • Identifier IPR029602
  • Description Intraflagellar transport protein 74

Abstract

Intraflagellar transport of ciliary precursors such as tubulin from the cytoplasm to the ciliary tip is required for ciliogenesis [ 1 ]. Intraflagellar transport protein 74 (IFT74) is a component of the intraflagellar transport (IFT) complex B, which contains at least 20 different protein subunits. Together with IFT81, it forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium [ 2 ].


1. Intraflagellar transport. Nat. Rev. Mol. Cell Biol. 3, 813-25
2. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science 341, 1009-12

Species distribution

Gene table