InterPro domain: IPR029523

This entry represents INO80 complex subunit 2 (Ies2), also known as INO80 complex subunit B (INO80B). INO80 is involved in transcriptional regulation, DNA replication and probably DNA repair [ 1 ]. Ies2 functions as a molecular switch that potently activates INO80 DNA-dependent ATPase activity [ 2 ].

1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. J. Biol. Chem. 280, 41207-12
2. Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex. Proc. Natl. Acad. Sci. U.S.A. 110, 20497-502