InterPro domain: IPR029399

The function of this family of transmembrane proteins is unknown. In vertebrates, proteins in this family are located in the lysosomal membrane and late endosome [ 1 , 2 ]. In Arabidopsis, a member of this family (protein FIP1) has been found to weakly interact with FRIGIDA, a determinant of flowering time [ 3 ].

1. Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane. Biol. Chem. 391, 695-704
2. Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers. Biochem. J. 434, 219-31
3. FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism involving direct interaction with the nuclear cap-binding complex. Plant Physiol. 150, 1611-8