InterPro domain: IPR029327

HAUS4 is part of the HAUS augmin-like complex, which contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [ 1 , 2 ].

Human augmin complex is composed of 8 subunits and interacts with the gamma-tubulin ring complex (gamma-TuRC) in centrosomes [ 3 ]. This interaction affects MT generation during mitosis and is critical for chromosome segregation and cytokinesis in human cells [ 3 ].

Similar to humans, Arabidopsis augmin complex also contains 8 subunits, including AUGMIN subunit 4 (AUG4) in this entry [ 3 ]. Despite lacking cetrosomes, the augmin complex in Arabidopsis also plays an important part in gamma-tubulin-dependent MT nucleation and the assembly of microtubule arrays during mitosis [ 4 ].

1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr. Biol. 19, 816-26
2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc. Natl. Acad. Sci. U.S.A. 106, 6998-7003
3. Characterization of the Arabidopsis augmin complex uncovers its critical function in the assembly of the acentrosomal spindle and phragmoplast microtubule arrays. Plant Cell 24, 1494-509