InterPro domain: IPR029131

This entry represents HAUS augmin-like complex subunit 5 (HAUS5) from eukaryotes. The HAUS augmin-like complex shares similarity with Drosophila Augmin that regulates gamma-tubulin localization in mitotic spindles, but not at the centrosome. It contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [ 1 , 2 ].

Plant and animal augmin complexes have similar functions in microtubule nucleation and organisation in mitotic microtubule arrays. The human augmin complex contains 8 subunits [ 3 ]. The Arabidopsis augmin complex contains both conserved and unique subunits compared with its animal counterparts [ 3 ]. This entry includes plant AUG5.

1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr. Biol. 19, 816-26
2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc. Natl. Acad. Sci. U.S.A. 106, 6998-7003
3. Characterization of the Arabidopsis augmin complex uncovers its critical function in the assembly of the acentrosomal spindle and phragmoplast microtubule arrays. Plant Cell 24, 1494-509