InterPro domain: IPR029067

This superfamily represents the CDC48 domain 2-like domain, which can be found in the N-terminal of the peroxisome biogenesis factor 1 and the domain 2 of the AAA ATPases.

CDC48 from yeasts is an AAA ATPase that is involved in protein export from the endoplasmic reticulum to the cytoplasm [ 1 ].

Peroxisome biogenesis factor 1, also known as peroxin-1 or PEX1, is a component of the peroxisomal protein import machinery. In addition to its role in import, PEX1 together with PEX6, mediates the ATP-dependent relocation and recycling of the peroxisomal targeting signal-1 (PTS1) import receptor PEX5 from the peroxisomal membrane to the cytosol [ 2 , 3 , 4 ].

1. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 414, 652-6
2. Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p. FEBS J. 272, 47-58
3. Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat. Cell Biol. 7, 817-22
4. Functional association of the AAA complex and the peroxisomal importomer. FEBS J. 273, 3804-15