InterPro domain: IPR029061

This entry represents the thiamin diphosphate-binding fold found in pyruvate dehydrogenases, branched chain alpha-keto acid decarboxylases, phosphoketolases and the pyrimidine binding region of transketolases [ 1 ]. There are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules. Two Pyr and two PP modules can assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules.

1. A thiamin diphosphate binding fold revealed by comparison of the crystal structures of transketolase, pyruvate oxidase and pyruvate decarboxylase. Structure 1, 95-103