InterPro domain: IPR029043

This superfamily represents a beta-barrel domain found at the C-terminal of the glycine cleavage T-protein (aminomethyltransferase) [ 1 ] and in tRNA-modifying protein YgfZ. YgfZ binds folate and is likely to be a folate-dependent regulatory protein [ 2 , 3 ].

1. Crystal structure of a component of glycine cleavage system: T-protein from Pyrococcus horikoshii OT3 at 1.5 A resolution. Proteins 58, 769-73
2. Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism. J. Bacteriol. 186, 7134-40
3. Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation. Mol. Microbiol. 59, 265-75