InterPro domain: IPR029038

All methionyl-tRNA synthetases (MetRS) display a highly conserved catalytic core with a Rossmann fold, the two halves of which are linked by a connective peptide (CP) [ 1 ]. In E. coli MetRS, a tightly bound zinc ion was shown to play a role in the folding of the CP region [ 2 ]. This entry represents the CP region.

1. Three-dimensional structure of methionyl-tRNA synthetase from Pyrococcus abyssi. Biochemistry 43, 2635-44
2. Crucial role of an idiosyncratic insertion in the Rossman fold of class 1 aminoacyl-tRNA synthetases: the case of methionyl-tRNA synthetase. Biochemistry 34, 15681-8