InterPro domain: IPR029032

This superfamily represents the alpha-helical domain found in alkyl-hydroperoxide reductase AhpD [ 1 ]. AhpD is a component of alkyl-hydroperoxide reductase participating in defense against ROS (reactive oxygen species) [ 2 ]. The C-terminal alpha-helical domain of the AhpD protein from Mycobacterium tuberculosis shares protein sequence and structural similarity with the N-terminal of Sesns from animals [ 3 ]. Sestrins (Sesns) are involved in ROS (reactive oxygen species) regulation [ 3 ].

A similar fold can also be found in other proteins such as 4-carboxymuconolactone decarboxylase (CMD) and some uncharacterised proteins [ 4 ].

1. The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J. Biol. Chem. 277, 20033-40
2. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 295, 1073-7
3. Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling. Antioxid. Redox Signal. 15, 1679-90
4. Crystal structure of the conserved protein TTHA0727 from Thermus thermophilus HB8 at 1.9 A resolution: A CMD family member distinct from carboxymuconolactone decarboxylase (CMD) and AhpD. Protein Sci. 15, 1187-92