InterPro domain: IPR029028

This entry represents a alpha/beta knot structural domain that can be found in many RNA methyltransferases, including members from the SPOUT superfamily, EMG1/NEP1 methyltransferases and SAM-dependent RNA methyltransferases. The alpha/beta knot structure is extremely rare in protein structures as it poses a folding problem [ 1 ].

1. Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): a cofactor bound at a site formed by a knot. Proteins 51, 56-67